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Sildenafil boosts the effect of NO by inhibiting phosphodiesterase type 5 (PDE5), that is liable for degradation of cGMP inside the corpus cavernosum. Sildenafil has no immediate relaxant impact on isolated human corpus cavernosum.At 24 several hours the plasma levels of sildenafil had been still close to 200 ng/mL, when compared to about five ng/m